El mercenario mutante malhablado Wade Wilson (alias Deadpool), reúne a un equipo de mutantes para proteger a un joven con habilidades sobrenaturales del brutal cyborg Cable, que viaja a través del tiempo.
Sinopsis en inglés:
After losing Vanessa (Morena Baccarin), the love of his life, 4th-wall breaking mercenary Wade Wilson aka Deadpool (Ryan Reynolds) must assemble a team and protect a young, fat mutant Russell Collins aka Firefist (Julian Dennison) from Cable (Josh Brolin), a no-nonsense, dangerous cyborg from the future, and must also learn the most important lesson of all: to be part of a family again.